Synthesis and Characterization Antifungal Fluorine Substituted Fused Heterobicyclic Nitrogen Systems Containing 1,2,4-triazine Moiety

Ola Ahmad Abu Ali

Abstract


Synthesis of some new full fluorinated heterobicyclic nitrogen systems containing 1,2,4-triazine moiety (4-10) have been deduced from heterocyclization of 6-(2'-trifluoroacetylamino)phenyl-3-(4'-fluorophenyl-1,2,4-triazin-5-one (3) with active oxo / halo-compounds. Structure of the products have been established upon their elemental and spectral date. Most of these systems exhibited a good to moderate antifungal activities.


Full Text:

PDF


DOI: https://doi.org/10.5539/jmbr.v8n1p41

Copyright (c) 2018 Ola Ahmad Abu Ali

License URL: http://creativecommons.org/licenses/by/4.0

Journal of Molecular Biology Research   ISSN 1925-430X (Print)   ISSN 1925-4318 (Online)   Email: jmbr@ccsenet.org

 

Copyright © Canadian Center of Science and Education

 

To make sure that you can receive messages from us, please add the 'ccsenet.org' domain to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', check your 'bulk mail' or 'junk mail' folders.