Effects of Tween-80 on the Dissolution Properties of Daidzein Solid Dispersion in Vitro

  •  Lijuan Hu    
  •  Na Zhang    
  •  Gengliang Yang    
  •  Jingyu Zhang    


Objective Solid dispersions of daidzein (DZ) were prepared using tween-80 as the surfactant to improve its
dissolution and solubility. Methods Using tween-80 as the surfactant and polyethylene glycol (PEG)-10000 as the
carrier, solid dispersions of DZ were prepared by solvent method. Infrared spectroscopy (IR) and X-ray diffraction
spectroscopy were applied to determine the status of DZ in carriers. Results When appropriate amount of Tween-80
was added into the solid dispersion, the dissolution of DZ could be improved obviously. The data of IR showed the
absence of well-defined drug-polymer interactions. The data of X-ray diffraction showed that the drug might exist in
the form of amorphism or molecule in solid dispersions. Conclusion Appropriate amount of Tween-80 could
increase the dissolution rate of DZ.

This work is licensed under a Creative Commons Attribution 4.0 License.
  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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