pH Metric Studies of Interaction of Synthesized Ligands 2-amino-4-hydroxy-6-methylpyrimidine and 1-(4-hydroxy-6-methylpyrimidino)-3-phenylthiocarbamide with Cu(II), Cd(II), Cr(II), Cations At 0.1 M Ionic Strength

Abstract

Guanidine was successfully interacted with acetoacetic ester to synthesize 2-amino-4-hydroxy-6-methylpyrimidine
(L1) which on further treatment with phenylisothiocyanate furnishes
1-(4-hydroxy-6-methylpyrimidino)-3-phenylthiocarbamide (L2). The interactions of Cu(II), Cd(II), Cr(II) metal ions
with L1 and L2 have been studied at 0.1 M ionic strength in 70 % Dioxane-water mixture by Bjerrum method as
adopted by Calvin and Wilson, It is observed that Cu(II), Cd(II), Cr(II) metal ions form 1:1 and 1:2 complexes with
ligands (L1 and L2). The data obtained were used to estimate and compare the values of proton-ligand stability
constant (pK.) and metal-ligand stability constants (log k).The effect of substituents were studied from estimated
data (pK & log k).