One-pot Preparation of ?–amino Carbonyl Compounds by Mannich Reaction Using MgO/ZrO2 as Effective and Reusable Catalyst

Nagrik D.M., Ambhore D.M., Gawande M.B.

Abstract


A new one-pot and efficient three-component condensation of aldehyde, ketones, and amines in the presence of MgO/ZrO2 as an inexpensive and effective catalyst for the synthesis of ?-amino carbonyl compounds by Mannich  reaction is described. The present methodology offers several advantages, such as good yields, Short reaction times and a recyclable catalyst with a very easy work up.

 

Keywords: Multi-component reaction, MgO/ZrO2, heterogeneous catalyst, ?-amino Carbonyl compounds.


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International Journal of Chemistry   ISSN 1916-9698 (Print)   1916-9701 (Online)

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