Synthesis of \beta-Lactam Fused Enediynes by Intramolecular Kinugasa


  •  Amit Basak    
  •  Runa Pal    
  •  Sanket Das    

Abstract

\beta-lactam fused enediynes have been successfully synthesized by intramolecular Kinugasa reaction in moderate yields.
DSC studies indicated significant influence of the \beta-lactam ring upon the reactivity of enediynes. None of the \beta-lactam
fused enediynes (under ring opening conditions) as well as the 11-membered monocyclic enediyne as the tosylate salt
showed any cleavage of plasmid DNA. Interestingly, the 10-membered enediyne as the tosylate salt cleaved both single
and double strands of plasmid DNA at micromolar concentration.


This work is licensed under a Creative Commons Attribution 4.0 License.
  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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