Synthesis of Derivatives of 6H-1,2-Oxazine by Cyclization of Ketoximes With Derivatives of Terminal Acetylene Compounds

Raad kasim Yahya, Narayana U. Kudva N., K. M. L. Rai


A new series of 6H-1,2-oxazines were synthesized by the reaction of ketones with hydroxylamine hydrochloride in the presence of sodium acetate to give ketoximes 1(a-e). Chloramine-T was used as an effective reagent for the generation of ?-nitrosolefins from ketoximes 1(a-e) which subsequently underwent hetero Diels-Alder reaction with terminal acetylenes 4(a-d), to give 6H-1,2-Oxazine derivatives 5(a-t).

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International Journal of Chemistry   ISSN 1916-9698 (Print)   ISSN 1916-9701 (Online)

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