Lipase Catalysed Kinetic Resolution of Stiripentol


  •  Elisabeth Egholm Jacobsen    
  •  Thorleif Anthonsen    
  •  Mohammed Farrag El-Behairy    
  •  Eirik Sundby    
  •  Mohamed Nabil Aboul-Enein    
  •  Mohamed Ibrahim Attia    
  •  Aida El-Sattar El-Azzouny    
  •  Kamilia M. Amin    
  •  Mohamed Abdel-Rehim    

Abstract

Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24. This allowed isolation of (3S)-Stiripentol with an ee of 86 % and the corresponding (3R)-butanoate with an ee of 87 %. Enzymatic hydrolysis of the ester product gave (3R)-Stiripentol with 94 % ee.


This work is licensed under a Creative Commons Attribution 4.0 License.
  • ISSN(Print): 1916-9698
  • ISSN(Online): 1916-9701
  • Started: 2009
  • Frequency: semiannual

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