Sperm DNA Fragmentation, Determined Using the Sperm Chromatin Dispersion (SCD) Test, A Study in Republic of Kosovo Population


  •  Afrim Zeqiraj    
  •  Sheqibe Beadini    
  •  Nexhbedin Beadini    
  •  Hesat Aliu    
  •  Zafer Gashi    
  •  Shkelzen Elezaj    
  •  Sadi Bexheti    
  •  Sanije Berisha    
  •  Agim Shabani    

Abstract

Infertility is a common condition affecting one in six couples of childbearing age. In approximately 40% of these cases, a male factor is involved. Sperm DNA integrity is essential for accurate transmission of genetic information. Materials and Methods: In this study 152 patients, 64 patients it is infertility group and 88 patients are fertile males. The ejaculate samples were taken in accordance with the patient to whom the reason for the analysis of the ejaculate sample was previously explained. All patients have been in the Dukagjini Region in the Republic of Kosovo. The samples were collected from 2016/18. Sperm Chromatin Dispersion (SCD) test, analysis in the ejaculate was performed at the Biolab Zafi, Laboratory in Peja, in the Republic of Kosovo. Statistical analysis: Data are reported as mean ± SD. The comparisons between groups were tested by student's t-test, ANOVA. A p-value less than 0.05% was considered statistically significant. Results: From our research studies, we have achieved significant (p <.00001) scores among the working group and control group across all sperm parameters, and DNA fragmentation. Conclusion: In summary, we have demonstrated that there was a negative correlation between DNA fragmentation, sperm motility, and morphology in infertile males. We conclude that sperm DNA fragmentation appears to be a useful technique to predict outcome in couples undergoing IVF/ICSI. To evaluate whether DFI 23.94 ± 4.68% can be used to determine male infertility in our country by Sperm Chromatin Dispersion (SCD), it is necessary to carry out further large-scale research by other authors.



This work is licensed under a Creative Commons Attribution 4.0 License.
  • ISSN(Print): 1916-9671
  • ISSN(Online): 1916-968X
  • Started: 2009
  • Frequency: quarterly

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