Tumor-suppressive and tumor-promoting role of Tgf-Beta in Hepatocellular Carcinoma

  •  Somyoth Sridurongrit    


Tgf-Beta is a pleiotropic cytokine with diverse functions on hepatic cells. The well-known function of Tgf-Beta in pathogenesis of liver disease is to stimulate liver fibrosis that often precedes the onset of liver cancer. While Tgf-Beta-mediated fibrosis seems to make liver more prone to the development of liver cancer, Tgf-Beta suppresses initial malignant transformation of hepatic cells thru regulation of proliferation and apoptosis. On the other hand, Tgf-Beta has shown to act as an inducer of tumor development thru enhancement of metastatic process. Additionally, it has been shown that Tgf-Beta signaling in hepatocytes promotes hepatocarcinogenesis caused by certain genetic conditions. This review highlights observations that have improved an understanding of how Tgf-Beta contributes to the development of hepatocellular carcinoma.

This work is licensed under a Creative Commons Attribution 4.0 License.
  • ISSN(Print): 1916-9671
  • ISSN(Online): 1916-968X
  • Started: 2009
  • Frequency: quarterly

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