Influence of Flaxseed on Lipid Profiles and Expression of LXRa, in Intestine of Diabetic Rat

  •  Abbas Mohammadi    
  •  Fateme Mirzaei    
  •  Mohammad Jamshidi    
  •  Reza Yari    
  •  Solmaz Pak    
  •  Parham Norouzian    
  •  Vahideh Abdolkarimi    
  •  Ebrahim Oshaghi    


The aim of this study is to examine the effect of flaxseed on lipid profiles in diabetic rats, focusing on intestinal LXR a. Animals were randomly divided into 3 groups of 8 rats each. group1: rats + chow diet (control), group 2: diabetic rats + chow diet (diabetic control), and group3: diabetic rats + chow diet + 4% flaxseed (w/w) (flaxseed group). After one-month rats were sacrificed, blood was collected; lipid profiles were determined enzymatically as well as mRNA and protein levels of SR-BI were determined by RT-PCR and westernblot respectively. Compared with diabetic control (group 2), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, and very low density lipoprotein cholesterol (VLDL-C) (all of them P < 0.01) significantly decreased in flaxseed group (group 3). Intestinal LXR a mRNA was significantly increased (P < 0.001) in flaxseed group treatment compared with diabetic animals (group 2). Levels of intestinal regulatory protein of LXR a significantly increased in flaxseed group (P < 0.05). In conclusion, flaxseedsignificantly reduced TC, LDL-C, TG, VLDL-C and atherogenic index, as compared with the diabetic rats (group 2). On the other hand flaxseed led to up-regulation of LXR a in the intestine of rats.

This work is licensed under a Creative Commons Attribution 4.0 License.
  • ISSN(Print): 1916-9671
  • ISSN(Online): 1916-968X
  • Started: 2009
  • Frequency: quarterly

Journal Metrics

Google-based Impact Factor (2017): 13.63
h-index (January 2018): 22
i10-index (January 2018): 75
h5-index (January 2018): 13
h5-median (January 2018): 16

Learn More