Comparison of Prevalence of Kaposi's Sarcoma in HHV8+ and HHV8- HIV Infected Patients in South-South Nigeria

Bob Agwu Ukonu, Emeka U. Eze, Abel N. Onunu

Abstract


This study was carried out to see if there are any differences between the prevalence of Kaposi’s sarcoma in HIV
infected patients with antibody to Human Herpes Virus 8 (HHV8) or not.
Methods: The sera of 180 subjects were evaluated for HIV and HHV8 using double ELISA (Genscreen Ultra
HIV Ag-Ab ELISA and JN HIV 1/2 ELISA Kit) for HIV screening and advanced Biotechnology Incorporated
ELISA for HHV8 IgG antibody detection respectively. Those HIV infected patients that had skin lesions
suspected to be Kaposi’s sarcoma were biopsied for histological diagnosis.
Results: A total of 180 subjects were recorded for this study. The ratio of male: female was 1:1.02. In all, 100
subjects tested positive to HIV screening and 87 (87%) patients tested positive to HHV8 antibody. Of the 87
patients that were positive to HHV8 antibodies 32 (36.7%) were histologically confirmed to have Kaposi’s
sarcoma.
Conclusion: We found a high rate of prevalence of Kaposi’s sarcoma KS among HIV infected patients with
HHV8 antibodies.

Full Text: PDF

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

Global Journal of Health Science   ISSN 1916-9736(Print)   ISSN 1916-9744(Online)

Copyright © Canadian Center of Science and Education

To make sure that you can receive messages from us, please add the 'ccsenet.org' domain to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', check your 'bulk mail' or 'junk mail' folders.