Abstract

Attention Deficit Hyperactivity Disorder is a psychiatric and behavioral disorder marked by chronic inattention and/or hyperactivity-impulsivity that interferes with functioning or development. This disorder is caused by many dysfunctions in the brain especially in the prefrontal cortex. To date, numerous studies have attempted to unravel the biological pathways behind ADHD. Many environmental risk factors have been identified including lead exposure and prenatal alcohol and tobacco exposure. Specific mutations in genes affecting dopamine and norepinephrine release are also under investigation. Moreover, around three thousand papers have been published showing that ADHD is due to an abnormal dopamine and norepinephrine neurotransmitters secretion in the prefrontal cortex (PFC). This paper aims to provide an updated review of the biological causes of ADHD with an unprecedented focus on different cellular pathways involving catecholamine secretion in the prefrontal cortex. A well rounded and comprehensive review of the etiology of ADHD would prevent its misdiagnosis by health professionals and consequently restrict its malpractice by the use of unnecessary treatments and medications. The ADHD controversy still remains: a disorder or a fraud?

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