Morphological Indicators of the Facies of Biological Fluids in Patients with Liver Diseases

The article discusses the results of morphometric studies of the solid phase serum of patients with liver disease. It is shown that the marker enzymes, minerals and proteins bioliquid facies (serum) obtained by dehydration wedge observed facies different zones.


Results and Discussion
Analysis blood serum crystallographic features let highlight 4 types of its structural organization in the pathology of the liver: partly radial, irradialny, circulatory and "three-fold".
The first type -partly radial had mild to moderate deviations from the radial-ordered arrangement of sectors, individual and nodules (Figure 1a.).
The second type -irradialny characterized by significant impairment on the systemic level.A feature of the third type -circulatory was the presence of large cracks, are arranged parallel to the edge facies between the peripheral and intermediate zones, the formation of which is determined by the circular distribution of the observed basic structures (Fig c .).
The structural pattern of the fourth type, is fundamentally different from the above types of facies serum did not contain the basic elements of her drawing was created by a network of small convoluted (three-prong) cracks that gave us a reason to call this type of "three-beam" (Figure 1g).The distribution of facies types of blood serum in patients examined is shown in Table 1.Thus, the serum of patients in the study using the method of wedge dehydration, with significant differences from the norm, is characterized by the presence of at least one of the major structural elements (large cracks, sectors, individual or nodules).
In addition to the identified changes in the main items of the facies in the structural organization of the serum examined patients determined a wide variety of abnormal structures.
Analysis of the results revealed the most typical and most common abnormal structure with cirrhosis who were treated leaf structure and various types of cracks, concentration, etc. are free.The hallmark of facies blood serum in liver disease was pathologically modified polymorphism cracks.There were cracks circulatory, knotted blocks, the structure of the "harness" in the central area and the periphery.
In the spectrum of the most frequently detected violations of local structural organization of the blood serum with liver cirrhosis leading position occupied by leaf-shaped structure, is a sign of sclerosis process, tri-radial cracksmarkers of stagnation.
Our results showed that leaf-shaped structure was significantly more common with cirrhosis than in patients with chronic hepatitis and moss figure rounded circular crack on and recorded at approximately the same frequency.
It is known that the pattern being the level of blood serum reflects the degree of tension of adaptive systems of the body: the pronounced adaptive response, the higher the activity of structure.In addition to the basic elements of the identified changes facies in crystallographic picture of blood serum of patients examined was determined by a wide variety of abnormal patterns (Table 2).As Table 2 shows that the dendrites enable rounded asymmetrical spaced apart, such as "plait" structure at the periphery and in the central zone occurs in a large amount (more than 50% cases) during the acute and chronic hepatitis.Circular cracks structure "harness" the type of circular waves, defective spherulites occur in chronic hepatitis and liver cirrhosis.Figures in the form of a "Mocha" and the presence of the zones found in all patients in the facies of blood serum.Zoning is available in all facies of patients examined.Measurement of the diameters of zones, shows that the relationship between them is almost the same in all cases.
We were the first in liver disease have been found, "moss" figure is a sign of increasing concentration of bilirubin in the blood.The figure of "moss" facies in serum in chronic liver disease and cirrhosis of the liver occurs 100%.The emergence of these types of crystals in the blood serum of patients mainly due to the increase in bilirubin, ALT, AST, and total protein.This is confirmed by the testimony of the biochemical laboratory of the Fergana regional infectious diseases hospital.
As a result of our research found that increasing excess of bilirubin (normal bilirubin 8.53-20.5 mmol / l), moss area of the figure is increased by 3,4 ± 0,3 mm 2. Thus, we can say that the blood bilirubin appears in the central area of its dried solid phase in the form of figures "Moss" type area that clearly correlates with the quantity (Botirov, Abdumanonov, & Karabaev, 2013).
It has been shown that more frequent during cirrhosis of the liver than in acute viral hepatitis and chronic hepatitis leaf, tri-radial cracks, and rounded on and circulatory crack recorded at approximately the same frequency.The incidence of the structure of the "harness" in the central zone of facies that are considered dehydration marker in chronic hepatitis was higher than in acute viral hepatitis and liver cirrhosis.

Conclusions
1) The blood serum of patients in the study using the method of wedge dehydration, with significant differences from the norm, is characterized by the presence of at least one of the major structural elements (large cracks, sectors, individual or nodules).In addition to the identified changes in the main items of the facies in the structural organization of the serum examined patients determined a wide variety of abnormal structures.
2) Revealed the most typical and most common abnormal structure with cirrhosis who were treated leaf structure and various types of cracks, concentration, etc. are free.The hallmark of facies serum in liver disease was pathologically modified polymorphism cracks.There were cracks circulatory, knotted blocks, the structure of the "harness" in the central area and the periphery.
3) It was found that the leaf structure was significantly more common with cirrhosis than in chronic hepatitis and moss figure rounded circular crack on and recorded at approximately the same frequency.
4) We were the first in liver disease have been found, "moss" figure is a sign of increasing concentration of bilirubin in the blood.
Figure facies characterized by asymmetry, the number of basic elements have been reduced, and their configuration is varied (Figure 1 b).
The types of structural organization of serum liver diseases

Table 2 .
The frequency of abnormal structures in the morphological picture of blood serum in liver disease