Synthesis of 6H-thiochromeno [3, 4-b] Quinoxaline Derivatives and their Antifungal Activities

Peng Wei, Jingjing Liu, Junjie Ma, Gengliang Yang

Abstract


Objective: To design to synthesize 6H-thiochromeno [3, 4-b] quinoxaline derivatives and evaluate their antifungal activities.

Methods: The target compounds were prepared from substituted thiophenol by several steps, and separated by column chromatography.

Results: Four new unreported compounds were obtained. All compounds were confirmed by 1 H NMR and MS spectral analysis. Preliminary pharmacological test showed that two compounds both possessed potential antifungal activities.

Conclusion: The synthesized 6H-thiochromeno [3, 4-b] quinoxaline derivatives had certain antifungal activities in some tested fungal strains in vitro.


Full Text: PDF

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

Modern Applied Science   ISSN 1913-1844 (Print)   ISSN 1913-1852 (Online)

Copyright © Canadian Center of Science and Education

To make sure that you can receive messages from us, please add the 'ccsenet.org' domain to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', check your 'bulk mail' or 'junk mail' folders.