In vitro Assessment of the Antioxidant Effect of Cunila microcephala Benth Infusion (Poejo) on Erythrocytes from Individuals with HIV/AIDS

Roberta Cattaneo Horn, Natacha Cossettin Mori, Juliana Sorraila de Oliveira, Paulo Ricardo Moreira, Janaina Coser, Janice de Fatima Pavan Zanella, Diego Pascoal Golle, Gabriela Tassotti Gelatti, Rodrigo Fernando dos Santos Salazar

Abstract


The aim of the present study is to investigate in vitro antioxidant activity of Cunila microcephala Benth infusion (Poejo) in erythrocytes from individuals with HIV/AIDS. Erythrocytes were used from seventeen patients of both sexes, with HIV/AIDS, receiving antiretroviral therapy and the control group consisted of erythrocytes of HIV/AIDS free individuals belonging to both sexes. The erythrocytes were treated in vitro for an hour with infusions of Poejo at the following concentrations: 1, 5, 10, 25 and 50 g/L After treatment, the levels of thiobarbituric acid reactive substances (TBARS), carbonylated proteins (CPs), and reduced glutathione (GSH) were measured. A reduction in lipoperoxidation and protein carbonylation was observed after treatment with poejo tea at the concentrations of 5, 10, 25 and 50g/L. In addition, a reduction of GSH at such concentrations was observed. Poejo infusion appears to perform an antioxidant activity in lipid oxidation and in the protein carbonylation found in individuals with HIV/AIDS.

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DOI: https://doi.org/10.5539/jas.v9n7p97

Copyright (c) 2017 Roberta Cattaneo Horn, Natacha Cossettin Mori, Juliana Sorraila de Oliveira, Paulo Ricardo Moreira, Janaina Coser, Janice de Fatima Pavan Zanella, Diego Pascoal Golle, Gabriela Tassotti Gelatti

License URL: http://creativecommons.org/licenses/by/4.0

Journal of Agricultural Science   ISSN 1916-9752 (Print)   ISSN 1916-9760 (Online)  E-mail: jas@ccsenet.org

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