Research on the Effect of Antioxidant Tabernaemontana catharinensis (Apocynaceae) on Erythrocytes Exposed to the Herbicide 2,4-Dichlorophenoxyacetic Acid

Roberta Cattaneo Horn, Luana Junges, Luana Pereira Magni, Natacha Cossettin Mori, Gabriela Tassotti Gelatti, Tamiris Felippin, Ana Caroline Tissiani, Mariana Spanamberg Mayer, Diego Pascoal Golle, Isis Amaral Thums


With the purpose of finding an alternative to mitigate the damaging effect of intoxication with 2,4-D (2,4-Dichlorophenoxyacetic acid), this research aims to determine whether Tabernaemontana catharinensis (cobrina) increases the antioxidant capacity and/or lowers the oxidative effects generated by the exposure to this herbicide. For the above purpose, blood samples were obtained from healthy volunteers. The erythrocytes were separated, exposed to the 2,4-D and treated with different concentrations of infusions of cobrina. Tests were conducted in a water bath at 37 °C for one hour. After the analytical determinations, it was verified that, with the duration of this test, the cobrina -even containing flavonoids in its composition- increased the oxidative damages in the proteins and lipids of the erythrocytes tested. 

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