Effect of Caffeine on Some Transferase Enzymes Activities

Abstract

This study was designed to show the effects of caffeine on the activities of aspartate aminotransferase (AST), alanine amino transferase (ALT), gama glutamate transferase (?-GT) enzymes in the sera. Caffeine demonstrated activation on (AST) and (ALT) activities, inhibitory effects on the (?-GT) activity, and these effects increased with increasing the concentration of the compound. Kinetic properties of (AST) and (ALT) activities revealed (by caffeine) non-competitive type of activation, and of (?-GT) activity competitive inhibitors