Synthesis and Antifungal Activity of (z)-3-(bromomethylene)thiochroman-4-ones

Baoling Fang, Zhengyue Ma, Gengliang Yang, Ge Wang, Wei Tian, Linbo Li

Abstract


Three (z)-3-(bromomethylene)thiochroman-4-ones were designed and synthesized. Their structures were confirmed by
MS and 1H NMR. In vitro antifungal activities of these synthesized compounds were evaluated against ten species of
fungi, and the results showed that the target compounds exhibited activity against fungi tested to some extent. The
maximum inhibitory activity was found for 3a against C.neoformans, 3a and 3c exhibited more potent antifungal
activities against C.Krusei than Fluconazole.

Full Text: PDF DOI: 10.5539/ijc.v2n1p143

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.

International Journal of Chemistry   ISSN 1916-9698 (Print)   1916-9701 (Online)

Copyright © Canadian Center of Science and Education

To make sure that you can receive messages from us, please add the 'ccsenet.org' domain to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', check your 'bulk mail' or 'junk mail' folders.