Studies on the Preparation of (S)-3-chloro-phenyl-1-propanol by Catalytic Asymmetric Hydrogenation of B-chloro-propiophenone

Abstract

The supported iron-based chiral catalysts were applied in the asymmetric catalytic hydrogenation reaction of B-chloro-propiophenone, and effects of the asymmetric catalytic reduction reaction temperature, pressure and KOH concentration on the output and e.e.value were investigated respectively. Results indicated that the reaction output and e.e. value attained 99% and 90%, respectively, when temperature, pressure and concentration was 60 ?, 1.2 MPa and 2×10-2 mol/L, respectively.