Synthesis and Characterization of Some New Azetidin-2-ones Containing Coumarin Moiety and Their Antimicrobial Study

Divyesh Patel, Niketan Patel, Premlata Kumari, Navin Patel

Abstract


A series of novel azetidinones 5a-i have been synthesized by cyclocondensation of various Schiff bases of coumarin with chloro acetyl chloride in presence of triethyl amine. The reaction of 4-hydroxy coumarin with POCl3 yielded 4-chloro coumarin 2 and 4-chloro-3, 4', 3', 4"-tercoumarin 2a. Compound 2 was reacted with p-phenylene diamine to yield 4-[(4-aminophenyl)amino]-2H-chromen-2-one. Various Schiff bases of coumarin were synthesized by condensation of 4-[(4-aminophenyl)amino]-2H- chromen-2-one with different aldehydes. The structures of the newly synthesized compound were confirmed by IR, 1H NMR, 13C NMR and C, H, N analysis. The Schiff bases and azetidnie-2-one derivatives were evaluated for their anti bacterial and antifungal activity by broth dilution method.


Full Text: PDF DOI: 10.5539/ijc.v3n2p117

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International Journal of Chemistry   ISSN 1916-9698 (Print)   ISSN 1916-9701 (Online)

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